Dr. Zopf's publications on Michigan Research Experts

Dr. Zopf's publications on PubMed

Select Publications


I have used 3D printing to develop numerous anatomic based devices, facilitating improvement in patient clinical care. I served as lead author on the first publication in literature using 3D printing to develop a patient specific implantable medical device. The device, a personalized 3D printed airway splint, was lifesaving and has continued to function as designed for over 20 children with severe tracheobronchomalacia. This report lays the foundation for future 3D printing in surgery and medicine. I speak regularly, nationally and internationally, about several applications for 3D printing that has catalyzed improvement in patient care. I have expertise for the entire innovative pathway, from idea conception, design, development, manufacturing, regulatory considerations, and successful clinical implementation.

a. Zopf DA, Hollister SJ, Nelson ME, Ohye RG, Green GE. Bioresorbable Airway Splint Created with a Three-Dimensional Printer. N Engl J Med. 2013 May 23;368(21):2043-5. doi: 10.1056/NEJMc1206319.

b. Hollister SJ, Flanagan CL, Zopf DA, Morrison RJ, Nasser H, Patel JJ, Ebramzadeh E, Sangiorgio SN, Wheeler MB, Green GE. Design Control for Clinical Translation of 3D Printed Modular Scaffolds. Ann Biomed Eng. 2015 Feb:1-13. PMCID: PMC4407657.

c. Zopf DA, Flanagan CL, Wheeler M, Green GE, Hollister SJ. Treatment of Severe Porcine Tracheomalacia with a 3-Dimensionally Printed, Bioresorbable, External Airway Splint. JAMA- Otolaryngol Head Neck Surg. 2014 Jan;140(1):66-71. PMCID: PMC4429780.

d. Les AS, Ohye RG, Filbrun AG, Ghadimi Mahani M, Flanagan CL, Daniels RC, Kidwell KM, Zopf DA, Hollister SJ, Green GE. 3D-printed, externally-implanted, bioresorbable airway splints for severe tracheobronchomalacia. Laryngoscope. 2019 Feb 22.

e. Nourmohammadi Z, Li ADR, Plott J, Powell A, Shih A, Zopf D. Self-Supported Nasopharyngeal Airway Device for Treatment of Hypotonic Upper Airway Obstruction. Accepted by Procedia CIRP (College International Pour La Recherche en Productiqu), Jan 2020.


I have leveraged innovation to advance care of obstructive sleep apnea and upper airway obstruction. My clinical practice implements the latest evidence based data to facilitate the highest level of clinical excellence for my patients. When adequate treatment options do not exist to satisfactorily meet the needs for my patients, I aim to create solutions that do meet those needs.

a. Gauger VT, Rooney D, Kovatch KJ, Richey L, Powell A, Berhe H, Zopf DA. A multidisciplinary international collaborative implementing low cost, high fidelity 3D printed airway models to enhance Ethiopian anesthesia resident emergency cricothyroidotomy skills. Int J Pediatr Otorhinolaryngol. 2018 Nov;114:124-128.

b. Kovatch KJ, Powell AR, Green K, Reighard CL, Green GE, Gauger VT, Rooney DM, Zopf DA. Development and Multidisciplinary Preliminary Validation of a 3-Dimensional-Printed Pediatric Airway Model for Emergency Airway Front-of-Neck Access Procedures. Anesth Analg. 2018 Sep 18.

c. Ali SA, Kovatch KJ, Hwang C, Bohm LA, Zopf DA, Thorne MC. Assessment of Application-Driven Postoperative Care in the Pediatric Tonsillectomy Population: A Survey-Based Pilot Study. JAMA Otolaryngol Head Neck Surg. 2019 Feb 7.

d. Dahl JP, Miller C, Purcell PL, Zopf DA, Johnson K, Horn DL, Chen ML, Chan DK, Parikh SR. Airway Obstruction during Drug-Induced Sleep Endoscopy Correlates with Apnea-Hypopnea Index and Oxygen Nadir in Children. Otolaryngol Head Neck Surg. 2016 Oct;155(4):676-80.

e. Ha JF, Morrison RJ, Green GE, Zopf DA. Computer-Aided Design and 3-Dimensional Printing for Costal Cartilage Simulation of Airway Graft Carving. Otolaryngol Head Neck Surg. 2017 Jun;156(6):1044-1047.


I implement innovative surgical techniques and leverage powerful technologies such as 3D printing to advance several surgical and reconstructive techniques. These clinical advancements are focused in the facial and craniofacial reconstructive as well as airway reconstructive fields.

a. Zopf DA, Mitsak AG, Flanagan CL, Wheeler M, Green GE, Hollister SJ. Computer aided-designed, 3-dimensionally printed porous tissue bioscaffolds for craniofacial soft tissue reconstruction. Otolaryngol Head Neck Surg. 2015 Jan;152(1):57-62.

b. VanKoevering KK, Zopf DA, Hollister SJ. Tissue Engineering and 3-Dimensional Modeling for Facial Reconstruction. Facial Plast Surg Clin North Am. 2019 Feb;27(1):151-161.

c. Reighard CL, Green K, Rooney DM, Zopf DA. Development of a Novel, Low-Cost, High-fidelity Cleft Lip Repair Surgical Simulator Using Computer-Aided Design and 3-Dimensional Printing. JAMA Facial Plast Surg. 2018 Nov 1. doi: 10.1001/jamafacial.2018.1237.

d. Zopf, DA, Iams W, Kim JC, Baker SR, Moyer JS. Full Thickness Skin Overlying a Separately Harvested Auricular Cartilage Graft for Nasal Alar Reconstruction. JAMA - Facial Plast Surg. 2013 Mar 1; 15(2):131-4.

e. Berens A, Newman S, Murakami C, Sie KC, Zopf DA. Computer-Aided Design and 3D Printing to Produce Costal Cartilage Model for Simulation of Auricular Reconstruction. Journal of the American Academy of Otolaryngology – Head and Neck Surgery. 2016, Aug;155(2):356-9. PMCID: PMC5828773.

f. Brennan JR, Cornettb A, Chang B, Crotts SJ, Nourmohammadi Z, Lombaert I, Hollister SJ, Zopf DA, Preclinical Assessment of Clinically Streamlined, 3D-Printed, Biocompatible Single- and Two-Stage Tissue Scaffolds for Ear Reconstruction. Journal of Biomedical Materials Research: Part B - Applied Biomaterials. 2020 Aug 04.

g. Chang B , Cornett A, Nourmohammadi Z, Law J, Weld B, Crotts SJ, Hollister SJ, Lombaert I, Zopf DA, Hybrid Three‐Dimensional–Printed Ear Tissue Scaffold With Autologous Cartilage Mitigates Soft Tissue Complications. Laryngoscope. 2020 Oct 06.